Abstract
Matrix metalloproteases (MMPs) are a family of well-known enzymes which operate prevalently in the extracellular domain, where they fulfil the function of remodeling the extracellular matrix (ECM). Within the 26 family members, encoded by 24 genes in humans, MMP-2 and MMP-9 have been regarded as primarily responsible for the basement membrane and peri-cellular ECM rearrangement. In cases of infiltrating carcinomas, which arise from the epithelial tissues of a gland or of an internal organ, a marked alteration of the expression and the activity levels of both MMPs is known to occur. The present investigation represents the continuation and upgrading of our previous studies, now focusing on the occurrence and intensity levels of MMP-2 and -9 and their proteomic correlations in a cohort of 80 breast cancer surgical tissues.
Highlights
Breast cancer (BC) is one of the most common types of cancer in women, resulting in more than one million cases annually with disparities in incidence and mortality worldwide [1,2]
We examined the activity levels of gelatinases in tissue samples from 80 breast cancer (BC) patients, diagnosed as ductal infiltrating carcinomas with histological grading G2/G3
We performed gelatin zymographies in 30 pairs of tumoral and non-tumoral tissues run in parallel with purified Matrix metalloproteases (MMPs)-2 and MMP-9 as a standard
Summary
Breast cancer (BC) is one of the most common types of cancer in women, resulting in more than one million cases annually with disparities in incidence and mortality worldwide [1,2]. BC is a heterogeneous disease, both at the inter- and intra-tumoral levels, leading to different prognostic implications: some carcinoma subtypes have a benign course, while others behave very aggressively and are potentially metastatic, causing treatment failure and probable mortality [3]. The prognosis for patients becomes worse in cases of late diagnosis [4]. A fundamental goal for both the diagnosis and therapy of patients is to increase the knowledge of cancer biology. Modern cancer research aims to provide information on the mechanisms leading to cell transformation and tumor progression to be used for the development of new markers and new therapies
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