Abstract
Rapid advances regarding the function and mode of actions of estrogens have resulted in the recognition that estradiol has a far greater role in biology than just its well known actions in the regulation of reproductive function. Its role in neuroprotection, synaptic plasticity, memory and learning has been a subject of intense investigation in the past decade, and its potential beneficial effects in delaying and ameliorating the effects of neurodegenerative disorders continues to be an important area of research. There is also extensive evidence that estrogens act via a rapid nongenomic mechanism of action as well as the classical genomic mechanism. This special issue attempts to provide current information on a number of aspects of estrogen signaling and actions in the brain.
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