Abstract
This article reviews our current understanding of the regenerative capacity of the corneal endothelium and critically evaluates new and important research in the treatment of endothelial dysfunction. The development and application of new surgical (Descemet’s membrane stripping only), pharmacologic (rho kinase inhibitors, such as ripasudil), and injectable cell culture modalities for the treatment of endothelial dysfunction have sparked debate in the cornea world and may revolutionize future clinical practice. The exact mechanisms involved in corneal endothelial regeneration remain elusive. The latest treatment strategies for endothelial dysfunction have the potential to transform our previous perceptions of endothelial physiology by eliciting new and exciting research questions for future investigations.
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