Abstract
Gastroesophageal reflux disease (GERD) is one of the most common problems in neonates. The main goals of infantile GERD treatment are maintaining clinical recovery, sufficient growth, and preventing the recurrence rate and related problems. Acid-suppressive therapy including H2RAs and PPIs are the basic pharmacologic therapy for adult and pediatric GERD. PPIs are more effective than H2RAs in GERD treatment. Neonatal GERD remains a difficult entity to define and manage, and additional studies to aid in the clinical diagnosis and management are needed. Neonatal GERD refractory to conservative and monotherapy is a dilemma and performing trials to evaluate the effect of a PPI or a H2RA plus prokinetics in the management of these neonates is necessary to prevent considering invasive diagnostic procedures and early surgical treatment. we performed three different clinical trials to survey the efficacy and safety of combined therapy including an H2RA plus a prokinetic or a PPI plus a prokinetic in neonatal GERD refractory to conservative and monotherapy. KEYWORDS: Neonates, Gastroesophageal reflux disease, refractory, treatment
Published Version (Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: EPRA International Journal of Multidisciplinary Research (IJMR)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.