Abstract
A specific inactivated vaccine for prevention of enzootic encephalomyelitis (Teschen disease) of swines was created. The vaccine is produced on the basis of «Dniprovskiy-34» strain of Porcine teschovirus-1 isolated in the Ukraine and adjuvant of ASRIAP. During vaccines production the original method of teshoviruses inactivation was used. A single vaccine dose of 2 cubic cm promotes specific swines immunity to Teschen disease remaining for 11 months. Protective antibody levels were observed on the 7th day after vaccination. The maximum level of virus neutralizing antibodies in the blood of vaccinated animals on 60th day have reached 1:8192. Geometric mean titer of antibodies is 1:512, which protects the vaccinated piglets even at intracerebral introduction of 10 lethal doses of control epizootic highly virulent strain of Teschen disease of swines «Chernihivskiy-2372». A high level of innovative product design was confirmed by commission tests conducted in cooperation with State Scientific Control Institute of Biotechnology and Microorganism Strains and protected with three patents of Ukraine for inventions and useful models. A normative product documentation (Technical Requirements of Ukraine, instructions for production and control and product insert) was created. Performed feasibility study of the «Teshovak» vaccine allows recommending it into the production and introduction into the practices of veterinary medicine.
Highlights
A high level of innovative product design was confirmed by commission tests conducted in cooperation with State Scientific Control Institute of Biotechnology and Microorganism Strains and protected with three patents of Ukraine for inventions and useful models
The vaccine is produced on the basis of «Dniprovskiy-34» strain of Porcine teschovirus-1 isolated in the Ukraine and adjuvant of ASRIAP
Ukraine is rapidly increasing the scale of application of immunological veterinary medicinal preparations, but existing domestic and foreign means for specific prevention of Teschen disease [1, 2] cannot satisfy pork producers for several reasons: antigenic discrepancy of production strains isolated in the early 70s of last century to epizootic [3], high reactogenicity of vaccines, lack of intensity of postvaccination immunity, multiple input, high products viscosity, etc
Summary
A specific inactivated vaccine for prevention of enzootic encephalomyelitis (Teschen disease) of swines was created. Ukraine is rapidly increasing the scale of application of immunological veterinary medicinal preparations, but existing domestic and foreign means for specific prevention of Teschen disease [1, 2] cannot satisfy pork producers for several reasons: antigenic discrepancy of production strains isolated in the early 70s of last century to epizootic [3], high reactogenicity of vaccines, lack of intensity of postvaccination immunity, multiple input, high products viscosity, etc. As a result of epizootic monitoring the low reactivity of swines vaccinated against Teschen disease was established, indicating a lack of immunogenicity of existing vaccines and the need for continuous monitoring of the intensity of post-vaccination immunity in farms and need of additional financial costs With this in mind, the goal of given study was to create an up-to-date domestic inactivated vaccine against the enzootic encephalomyelitis of swines – «Teshovak»
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