Abstract
New icetexane diterpenes ( 1– 2); 8, 11, 13-icetexatriene-10-hydroxy, 11, 12, 16-tri acetoxyl ( 1) and 8, 11, 13-icetexatriene-7, 10, 11-dihydroxy-12, 13-dihydrofuran ( 2) along with six known compounds namely acetoxy syranzaldehyde ( 3), syranzaldehyde ( 4), coniferaldehyde ( 5), lupeol ( 6), betulin ( 7), and 4-(4-methoxy phenyl)-2-butanone ( 8) were isolated from the roots of Premna tomentosa. The structures of compounds 1 and 2 were established by detailed spectral analysis using UV, IR, 1H NMR, 13C NMR, 1D, 2D and Mass. The newly isolated compounds were screened for rat intestinal α-glucosidase inhibitory and free radical (DPPH) scavenging potentiality. The new icetexane diterpenes ( 1, 2) and compound 3 were found to have significant α-glucosidase inhibitory and also free radical scavenging (DPPH) activities.
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