Abstract
This study reports a strategy for developing a biohybrid complex based on a natural/synthetic polymer conjugate as a gel-type structure. Coupling synthetic polymers with natural compounds represents an important approach to generating gels with superior properties and with potential for biomedical applications. The study presents the preparation of hybrid gels with tunable characteristics by using a spiroacetal polymer and alginate as co-partners in different ratios. The new network formation was tested, and the structure was confirmed by FTIR and SEM techniques. The physical properties of the new gels, namely their thermal stability and swelling behavior, were investigated. The study showed that the increase in alginate content caused a smooth increase in thermal stability due to the additional crosslinking bridges that appeared. Moreover, increasing the content of the synthetic polymer in the structure of the gel network ensures a slower release of carvacrol, the encapsulated bioactive compound.
Highlights
Hydrogels are three-dimensional, cross-linked networks of polymers and their individual physical properties are of particular interest for use in drug delivery applications, including in pharmaceutical patches or Transdermal Therapeutical Systems (TTS)
New gel network systems based on PITAU and alginate were developed in order to observe their characteristics, and to predict their potential applications in the biomedical and pharmaceutical fields
The study underlined the dependence of the swelling properties of the synthesized networks on the ratio between PITAU and Alg co-partners
Summary
Hydrogels are three-dimensional, cross-linked networks of polymers and their individual physical properties are of particular interest for use in drug delivery applications, including in pharmaceutical patches or Transdermal Therapeutical Systems (TTS). Hydrogels based on combinations between natural and synthetic polymers offer significant advantages, e.g., tunable mechanical properties, increased water content, enhanced biocompatibility and appropriateness to body tissue, and possibility of attaching chemical clues for further superior interfacial interactions. The use of polysaccharides as a base for the three–dimensional network structure preparation—recommended due to their properties such as biocompatibility, obtainment from renewable sources, and possibilities of “green” procedures for their modifying—is of major interest [1,7]. Among these compounds, the alginate has an important place. This studoynpresents thaelgpinreaptearation of bainodconjugatedpgoelyls(ibtaacsoendicon alginateaannhdypdorliyd(eit-accoo-3n,i9c-danivhiyndyrl-i2d,e4-,c8o,1-30,-9te-dtriavoinxyasl-p2i,r4o,8[5,1.50-]tuentrdaeocxaansep)i.roT[h5e.5]nuenwdepcarenpe)a.rTedhesntreuwctpurree-s pwareerde cshtraurcatcutreersizwederferocmharsatrcutecrtiuzreadl,fmroomrpshtroulcotguircaall,, manodrpthhoerlomgaiclable, hanavdiothreprmoinaltsboehf avvieiowr. points of view
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