Abstract
We synthesized novel water-soluble and orally active taxane analogues, 7-deoxy-9β-dihydro-9,10- O-acetal taxanes. Cytotoxicities of the synthetic compounds were greater than those of paclitaxel and docetaxel, especially against resistant cancer cell lines expressing P-glycoprotein. In addition, some compounds showed potent antitumor effects against B16 melanoma BL6 in vivo by both iv and po administration.
Published Version
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