Abstract
associated with nominal significance (p<10-5); and (2) at a second region on chr.4, ~37 Mb away, with the combined ASCA, I2, CBir1 and Ompc Z-score (rs2995965 plinear= 1.35x10-9, β=0.82; rs1863284 plinear=1.71x10-7, β=0.85; rs2911920 plinear=6.29x10-6, β=0.61). RELL1, a homologue of RELT the TNF receptor that induces epithelial cell apoptosis is located at this locus. Conclusions: These observations suggest that these two loci contribute to the phenotypic difference of UC patients, one for UC severity as typified by ANCA level, the other for the expression of antibodies more characteristic of CD. Studies to assess the phenotypic differences tagged by these SNPs within the UC population are in progress.
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