New genetic and practical implications of selection for anthelmintic resistance in parasitic nematodes

Abstract

Investigations into genetic mechanisms underlying anthelmintic resistance in parasitic nematodes have indicated that even at moderate levels of resistance, reversion to the initial level of susceptibility may be impossible. Alleles that confer the higher levels of susceptibility may be lost from the population in the early stages of selection. Therefore close monitoring of early steps in the selection for resistance is needed, as discussed here by Marleen Roos. Marcel Kwa and Warwick Grant.