Abstract
This Special Issue on intervertebral disc (IVD) regeneration focuses on novel advances in understanding the cell sources and culture conditions of various cell types, i.e., progenitor and IVD cells. The issue consists of seven articles that provide a comprehensive overview of recently applied research insights: (1) into how IVD herniation can be provoked in a controlled in vitro biomechanical testing set-up, (2) how cells can be used for IVD repair, (3) the physiological conditions of IVD cells and (4) how hyaluronic acid could be used for IVD repair, and (5) how nucleus pulposus progenitor cells (NPPCs) and mesenchymal stromal cells (MSCs) shall be cultured and expanded towards a possible cell therapy.
Highlights
Current approaches to regenerate the entire intervertebral disc (IVD) or parts of IVDs are not very successful
Lower back pain (LBP) is a dominant medical problem that affects billions of people worldwide, yet no cure is in close sight
Tissue-engineered solutions have been developed to target a biological and, hopefully, more physiological solution to the problem. This Special Issue provides a cross-disciplinary section of “applied science” in this field of biomedical research ranging from biomechanics [1], biomaterials such as hyaluronic acid (HA) [2], and cell physiology [3] to in vitro cell culture studies on how cell phenotypes should be directed towards more IVD-like cells [4,5,6]
Summary
Current approaches to regenerate the entire IVD or parts of IVDs are not very successful. New Frontiers towards Regeneration of the Intervertebral Disc: On Progenitor Cells, Growth Factors and Biomaterials. This Special Issue provides a cross-disciplinary section of “applied science” in this field of biomedical research ranging from biomechanics [1], biomaterials such as hyaluronic acid (HA) [2], and cell physiology [3] to in vitro cell culture studies on how cell phenotypes should be directed towards more IVD-like cells [4,5,6].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
