Abstract
This Special Issue on intervertebral disc (IVD) regeneration focuses on novel advances in understanding the cell sources and culture conditions of various cell types, i.e., progenitor and IVD cells. The issue consists of seven articles that provide a comprehensive overview of recently applied research insights: (1) into how IVD herniation can be provoked in a controlled in vitro biomechanical testing set-up, (2) how cells can be used for IVD repair, (3) the physiological conditions of IVD cells and (4) how hyaluronic acid could be used for IVD repair, and (5) how nucleus pulposus progenitor cells (NPPCs) and mesenchymal stromal cells (MSCs) shall be cultured and expanded towards a possible cell therapy.
Highlights
Current approaches to regenerate the entire intervertebral disc (IVD) or parts of IVDs are not very successful
Lower back pain (LBP) is a dominant medical problem that affects billions of people worldwide, yet no cure is in close sight
Tissue-engineered solutions have been developed to target a biological and, hopefully, more physiological solution to the problem. This Special Issue provides a cross-disciplinary section of “applied science” in this field of biomedical research ranging from biomechanics [1], biomaterials such as hyaluronic acid (HA) [2], and cell physiology [3] to in vitro cell culture studies on how cell phenotypes should be directed towards more IVD-like cells [4,5,6]
Summary
Current approaches to regenerate the entire IVD or parts of IVDs are not very successful. New Frontiers towards Regeneration of the Intervertebral Disc: On Progenitor Cells, Growth Factors and Biomaterials. This Special Issue provides a cross-disciplinary section of “applied science” in this field of biomedical research ranging from biomechanics [1], biomaterials such as hyaluronic acid (HA) [2], and cell physiology [3] to in vitro cell culture studies on how cell phenotypes should be directed towards more IVD-like cells [4,5,6].
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