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Abstract
New frontiers in the neuropsychopharmacology of mental illness.
Highlights
This Research Topic aims to cover recent progress in research studying how genetic make-up and environmental factors can contribute to the development of mental disorders such as anxiety, depression, schizophrenia, and psychoactive substances abuse
By performing loose-seal cell-attached electrophysiological recordings in 5-HT transporter knockout (Sert−/−) and tryptophan hydroxylase-2 knockout (Tph2−/−) mice, Araragi et al (2013) demonstrate that the sensitivity of somatodendritic 5-HT1A receptors does not predict the magnitude of 5-HT neuron auto-inhibition
Mendez-David et al.’s (2013) results suggest that isolation of peripheral blood mononuclear cells (PBMCs) from mice by submandibular bleeding is a useful technique to screen putative biomarkers relevant to the pathophysiology of mood disorders such as β-arrestin 1
Summary
This Research Topic aims to cover recent progress in research studying how genetic make-up and environmental factors can contribute to the development of mental disorders such as anxiety, depression, schizophrenia, and psychoactive substances abuse. The first three articles describe several techniques which are valuable tools to study the role of neurotransmitters such as serotonin (5-HT) in the pathophysiology and the treatment of psychiatric disorders. The following eleven articles provide excellent insights into the interaction between gene and environment in mental disorders as well as the role of several transmitters/neuropeptides and the different therapeutic strategies.
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