Abstract
Cardiovascular disease (CVD) is one of the leading causes of death worldwide. In recent years, regenerative medicine, tissue engineering and the development of new materials have become the focus of attention this field, and electrospinning technology to prepare nanofibrous materials for the treatment of cardiovascular diseases has attracted people's attention. Unlike previous reviews, this research enumerates the experimental methods and applications of electrospinning technology combined with nanofibrous materials in the directions of myocardial infarction repair, artificial heart valves, artificial blood vessels and cardiovascular patches from the perspective of cardiovascular surgery. In the end, this review also summarizes the limitations, unresolved technical challenges, and possible future directions of this technology for cardiovascular disease applications.
Highlights
In 1985, Weinstein and Stason [1] have reported that coronary heart disease (CHD) is the leading cause of death and disability in the United States
According to the American Heart Association (AHA) estimates, by 2035, 46.1% of the US population will have some form of cardiovascular disease, when the total cost associated with cardiovascular disease will be 1.1 trillion dollars [3], which is enough to see the great harm and burden of cardiovascular disease to humans
In order to establish a model for evaluating the performance of engineered heart in vitro, Polylactic acid (PLA) and poly-εcaprolactone (PCL) were used to fabricate the porous scaffold via 3D printing and electrospinning, and cardiomyocytes from neonatal Sprague Dawley (SD) rats were cultured on the PLA/PCL scaffold to construct the engineered cardiac tissue (ECT)
Summary
In 1985, Weinstein and Stason [1] have reported that coronary heart disease (CHD) is the leading cause of death and disability in the United States.
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