Abstract
A number of new 4-anilinoquinazolines were synthesized starting from 6,7,8-trifluoro-2-(methylsulfanyl)quinazolin-4(3H)-one. Reactions of the title compounds with cyclic secondary amines involved substitution of the 7-fluorine atom with retention of the methylsulfanyl group on C2. 6,7,8-Trifluoro-4-(2-methoxyanilno)-2-(methylsulfanyl)quinazoline showed in vitro tuberculostatic activity with a minimum inhibitory concentration of 1.5 μg/mL.
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