New flavonol glycosides from the leaves of Allium victorialis var. platyphyllum

Abstract

Allium victorialis var. platyphyllum (Liliaceae) is widely distributed in the northern part of Korea. The bulbs and leaves of this plant have been used as vegetable in Korea and also used as Korean traditional medicine for the treatment of gastritis and heart failures. Previous phytochemical studies on this plant reported the isolation of flavonoids, steroidal saponins and sulfur compounds. In the course of our continuing search for bioactive compounds from Korean medicinal plant sources, we investigated the 80% MeOH extract of the leaves of A. victorialis var. platyphyllum. Column chromatographic purification of the MeOH extract resulted in the isolation of eight new flavonol glycosides, named Allivictoside A-G (1-8), together with twelve known flavonoids (9-20). The structures of new ones were determined on the basis of 1D and 2D NMR data and chemical means. We are studying the anti-neuroinflammatory effects of the isolates for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells.