Abstract
The biological potential of ferrocene cyclopalladated compounds as anticancer agents has garnered significant attention. However, the limited availability of these compounds due to their sparse synthesis constrains the broader exploration of their anticancer mechanisms. In this paper, we report the synthesis and comprehensive characterization of four novel ferrocene cyclopalladated compounds (C1, C2, C3, and C4) employing ¹H, ¹³C NMR, ESI-MS, and elemental analysis techniques. The molecular structures of C1 and C3 were determined by X-ray single-crystal diffraction. Furthermore, when tested in vitro, these compounds exhibited superior inhibition of mouse melanoma cell (B16F10) proliferation compared to cisplatin. Notably, compound C2 displayed approximately 17-fold higher potency against mouse lymphoma cells (YAC-1) than cisplatin. This enhanced efficacy signifies the promising role of ferrocene cyclopalladated compounds in anticancer therapies.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
