Abstract
1School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong 2Division of Gastroenterology and Hepatology, Queen Mary Hospital and Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong 3Centre for Integrative Chinese Medicine and Department of Renal Sciences, Division of Transplantation Immunology and Mucosal Biology, MRC Centre for Transplantation, Faculty of Life Sciences & Medicine, King’s College London, London WC2R 2LS, UK 4Zebrafish Centre for Advanced Drug Discovery, Keenan Research Centre of Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital & Department of Medicine, Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8 5Division of Gastroenterology and Hepatology, Department of Internal Medicine, Edward Doisy Research Center, Saint Louis University School of Medicine, St. Louis, MO 63104, USA
Highlights
Regardless how the diseases are initiated, without proper intervention, Chronic liver diseases (CLD) may gradually progress towards end-stage liver disease (ESLD), for which liver transplantation remains the only solution
With untargeted metabolomics combined with bioinformatic approaches, the team unveiled potential mechanisms underlying the therapeutic effect of turmeric extract in treating nonalcoholic fatty liver diseases (NAFLD)
Some pioneering attempts have been made since 2009 to develop and disseminate good practice guidelines on Chinese Medicine research [7, 8]. Further development of such guidelines would heavily rely on international, intersectoral, and interdisciplinary collaborations. Another challenge in the current research on traditional medicine is the uncertainty of mechanisms of action and the possibility of multiple targets
Summary
Chronic liver diseases (CLD) are serious health-threatening problems worldwide. It is a significant healthcare burden in Southeast Asian countries where viral hepatitis is common. Regardless how the diseases are initiated, without proper intervention, CLD may gradually progress towards end-stage liver disease (ESLD), for which liver transplantation remains the only solution. This progression may be slow and gradual, there is no evidence showing that it could be reversed when cirrhosis has developed. Drug resistance and various adverse effects can lead to failure of treatment Many countries have their own traditional medicines and herbal medicines are the main therapeutic materials in most traditional medicines. The main goal of this special issue is to showcase the latest research in this research area to promote academic exchanges and disseminate the state of the art
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