Abstract
The Eph receptor tyrosine kinases and their ephrin ligands play a pivotal role during axon pathfinding and neural circuitry formation. A prominent way in which Eph receptors sculpt cellular morphology is by remodeling the actin cytoskeleton and the surrounding plasma membrane through the regulation of Rho family GTPases. Two articles in this issue of Neuron (Sahin et al. and Cowan et al.) shed light on how Eph receptors recruit guanine nucleotide exchange factors for Rho family GTPases to modulate growth cone dynamics.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.