Abstract
Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the methanolic extract of Briareum asbestinum collected in Bocas del Toro, on the Caribbean side of Panama, led to the isolation of three new eunicellin-type diterpenes: briarellin T (1), asbestinin 27 (2), asbestinin 28 (3) and the previously described asbestinin 17 (4). The structures of the new compounds were determined by extensive NMR analyses and HRMS. Anti-inflammatory activity assays showed a significant reduction of the pro-inflammatory cytokines TNF-α, IL-6, IL-1β and IL-8 as well as a downregulation of COX-2 expression in LPS-stimulated THP-1 macrophages. These findings support the potential use of these marine compounds as therapeutic agents in the treatment of inflammatory diseases.
Highlights
IntroductionAcute inflammation is a biological response to pathogens, toxic agents, tissue damage or radiation.This process is a defense mechanism aimed to remove harmful stimuli and restore tissue homeostasis.uncontrolled acute inflammation can trigger a chronic inflammatory process, which is related to several diseases, such as cancer, rheumatoid arthritis, asthma, inflammatory bowel disease, multiple sclerosis, or cardiovascular diseases [1]
Acute inflammation is a biological response to pathogens, toxic agents, tissue damage or radiation.This process is a defense mechanism aimed to remove harmful stimuli and restore tissue homeostasis.uncontrolled acute inflammation can trigger a chronic inflammatory process, which is related to several diseases, such as cancer, rheumatoid arthritis, asthma, inflammatory bowel disease, multiple sclerosis, or cardiovascular diseases [1]
The octocoral Briareum asbestinum was collected by hand using SCUBA at 10 m in Isla San Cristobal, The octocoral Briareum asbestinum was collected by hand using SCUBA at 10 m in Isla San
Summary
Acute inflammation is a biological response to pathogens, toxic agents, tissue damage or radiation.This process is a defense mechanism aimed to remove harmful stimuli and restore tissue homeostasis.uncontrolled acute inflammation can trigger a chronic inflammatory process, which is related to several diseases, such as cancer, rheumatoid arthritis, asthma, inflammatory bowel disease, multiple sclerosis, or cardiovascular diseases [1]. Acute inflammation is a biological response to pathogens, toxic agents, tissue damage or radiation. This process is a defense mechanism aimed to remove harmful stimuli and restore tissue homeostasis. Uncontrolled acute inflammation can trigger a chronic inflammatory process, which is related to several diseases, such as cancer, rheumatoid arthritis, asthma, inflammatory bowel disease, multiple sclerosis, or cardiovascular diseases [1]. Many researchers are focused on the search for new anti-inflammatory molecules, since there is interest in finding more effective therapies with fewer side effects than those currently used. The need of new therapeutic compounds has given rise to a vast number of studies in marine environments, a resource with huge potential for drug development [2,3].
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