Abstract
Four new eudesmane-type sesquiterpenoids, penicieudesmol A–D (1–4), were isolated from the fermentation broth of the mangrove-derived endophytic fungus Penicillium sp. J-54. Their structures were determined by spectroscopic methods, the in situ dimolybdenum CD method, and modified Mosher’s method. The bioassays results showed that 2 exhibited weak cytotoxicity against K-562 cells.
Highlights
Mangrove forests, the unique forest ecosystems distributed in most tropical and subtropical regions, are an important resource of endophytic fungi that have been proved to be an important source of structurally and biologically diverse substances [1,2,3,4,5,6,7,8,9] such as peniphenones A–D, aniquinazolines A–D, phomazines A–C, and so on [10,11,12]
The absolute configuration of the 1,2-diol moiety in 1 was determined by the in situ dimolybdenum CD method developed by Snatzke and Frelek [14,15,16]
The results showed that compound 2 exhibited weak cytotoxicity against K-562 with IC50 value of
Summary
Mangrove forests, the unique forest ecosystems distributed in most tropical and subtropical regions, are an important resource of endophytic fungi that have been proved to be an important source of structurally and biologically diverse substances [1,2,3,4,5,6,7,8,9] such as peniphenones A–D, aniquinazolines A–D, phomazines A–C, and so on [10,11,12]. FJ-1 isolated from the stem of Ceriops tagal were studied, and a new drimane-type sesquiterpene [13]. Four eudesmane-type new sesquiterpenoids, penicieudesmol A–D (1–4) (Figure 1), were obtained from the culture broth of the Penicillium sp. J-54 isolated from the healthy leaves of Ceriops tagal collected in Dong Zhai Gang Mangrove Reserve in Hainan. We described the isolation, structure determination, and biological activities of the new sesquiterpenoids 1–4
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