Abstract
New era of liver transplantation for HIV-HCV Co-infected patients: A case report
Highlights
Widespread implementation of highly active antiretroviral therapy (HAART) has improved dramatically the life expectancy of human immunodeficiency virus (HIV)-infected patients [1] and with this increase in life expectancy, illnesses such as chronic kidney and chronic liver disease constitute a new challenge in HIV-infected patients [2]
hepatitis C virus (HCV)-HIV co-infection is associated with exceedingly poor outcomes after orthotopic live transplantation (OLT), with regard to both patient and graft survival rates; mainly due to a higher rate and worse phenotypes of rejection in that population [5]
The causative factors are primarily hepatitis C virus recurrence which leads to liver ibrosis/cirrhosis and HIV infection which accelerates the pathophysiologic process, through immunosuppression [6]
Summary
New era of liver transplantation for HIV-HCV Co-infected patients: A case report. Konstantinos A Zorbas*, Sunil S Karhadkar, Kwan N Lau, Andreas Karachristos and Antonio Di Carlo. Lewis Katz School of Medicine at Temple University Hospital, Department of Surgery, Philadelphia, PA, USA. Submitted: 03 November 2017 Approved: November 2017 Published: November 2017. Research highlights: The advent of DAA drugs has given the opportunity in HCV-HIV population to counter the deleterious effect of HCV on liver allografts after transplantation. In our opinion HIV-HCV co-infection is no longer a contraindication for liver transplantation
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