Abstract

<h3>Background</h3> Patients with coronary heart disease (CHD) who are depressed have an increased risk of further cardiac events and higher mortality. <h3>Aim</h3> To use a patient generated instrument (PSYCHLOPS) to define categories of concerns in patients with CHD. To define the psychometric characteristics of patients in each category. <h3>Design and setting</h3> Cross-sectional study set in general practices in south London. <h3>Method</h3> Of 3325 patients on the CHD registers in 15 general practices, 655 completed six baseline psychometric and functional instruments: PSYCHLOPS, HADS-Depression, HADS-Anxiety, Clinical Interview Schedule – Revised, SF12-Mental and SF12-Physical. Content analysis was used to categorise patients based on their main problem, as elicited by PSYCHLOPS. Mean psychometric scores were adjusted for confounding by age, sex, deprivation and ethnicity and calculated for each response category. <h3>Results</h3> Response categories were: physical problems, both non-cardiac (23.2%) and cardiac (6.0%); social problems: relationship/family (18.2%), money (7.5%), work (3.1%); functional (9.8%); psychological (6.9%); miscellaneous (7.3%); ‘no problem’ (18.2%). The highest psychological distress scores were found in ‘physical, cardiac’ and ‘psychological’ categories. The ‘no problem’ category had significantly lower psychological distress and higher functional capacity than other categories. <h3>Conclusions</h3> PSYCHLOPS enabled the identification of subtypes of CHD patients, based on a classification of self-reported problems. A high proportion of CHD patients report social problems. Psychological distress was highest in those reporting cardiac or psychological symptoms. Services should be aligned to the reported needs of patients.

Highlights

  • Developing stable formulations is generally a common target to obtain efficacious emulsified vaccines

  • New equipment optimized for emulsified vaccine prepation in the hospital

  • In the hospital obtaining reproducible and stable water in oil (W/O) emulsions is a challenge for the pharmacy or the operators involved

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Summary

Introduction

Developing stable formulations is generally a common target to obtain efficacious emulsified vaccines. New equipment optimized for emulsified vaccine prepation in the hospital Process used to perform water in oil (W/O) emulsions are not all equivalent regarding vaccines physico-chemical parameters. Equipment generally used to realise emulsified vaccines can be high shear mixers, vortex, syringes, or syringes connectors.

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