Abstract
In continuation to our study of the chemical and biological potential of the secondary metabolites isolated from Omani seaweeds, we investigated a marine brown alga, Padina boergesenii. The phytochemical investigation resulted in the isolation of a new secondary metabolite, padinolic acid (1), along with some other semi-pure fractions and sub-fractions. The planar structure was confirmed through MS and NMR (1D and 2D) spectral data. The NOESY experiments coupled with the biogenetic consideration were helpful in assigning the stereochemistry in the molecule. Compound 1 was subjected to enzyme inhibition studies using urease, lipid peroxidase, and alpha-glucosidase enzymes. Compound 1 showed low to moderate α-glucosidase and urease enzyme inhibition, respectively, and moderate anti-lipid peroxidation activities. The current study indicates the potential of this seaweed and provides the basis for further investigation.
Highlights
Man has been using the oceans as a useful resource for producing economically important materials [1]
As a rarely on P. boergesenii, the present study was conducted to search for secondary metabolites with result, one new secondary metabolite, padinolic acid (1) (Figure 1), was isolated along with some other biological activities
In addition to enzyme inhibition, the isolated compound was analyzed for inhibiting the level of lipid peroxidation. This was performed by a modified method of thiobarbituric acid reactive substances (TBARS) [34]
Summary
Man has been using the oceans as a useful resource for producing economically important materials [1]. Brown algae are reported to possess a broad range of bioactive carotenoids, polysaccharides, and polyphenols with physiological effects on human health [7,8]. The secondary metabolites from organisms living in the marine environment have been found to possess ameliorative potential in the exploration of drugs for various human-associated diseases Ailments such as diabetes are regarded serious metabolic disorders in the human body. The common secondary metabolites of brown algae include long‐chain fatty acids, polyphenols,effects polysaccharides, triterpenoids, and carotenoids, etc., with and curative physiological on human sterols, health [7]. As a rarely on P. boergesenii, the present study was conducted to search for secondary metabolites with result, one new secondary metabolite, padinolic acid (1) (Figure 1), was isolated along with some other biological activities. Enzyme‐inhibitory activity against lipid peroxidase, α‐glucosidase, and urease enzymes
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