Abstract
(+)- and (−)-etodolac enantiomers were prepared both by classical resolution via crystallisation of diastereoisomeric salts with (+) and (−)-α-methylbenzylamine, and by suitable manipulation of derivatives (−)- 3- and (+)- 4, obtained by lipase-catalysed kinetic resolution of racemic 3 X-ray diffraction analysis of the 4-bromobenzoate derivative of (+)- 3, obtained from enantiopure acetate (+)- 4, allowed us to determine the absolute (R) configuration of (−)-etodolac.
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