Abstract

A new entry to chiral butenolide synthons starting with iodolactonization of the readily available, homochiral N-benzyl- N-methyl-3-hydroxy-4-pentenamide ( 1) and its application to the syntheses of (+)-nephrosteranic acid ( 5), (+)- trans-whisky lactone ( 6), and (+)- trans-cognac lactone ( 7) are described.

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