New EMPIR project – Metrology for Drug Delivery

E Batista,A Furtado,J Pereira,M Ferreira,H Bissig,E Graham,A Niemann,A Timmerman,J Alves E Sousa,F Ogheard,A.W Boudaoud

doi:10.1016/j.flowmeasinst.2020.101716

Abstract

This document presents the scientific and technical objectives, state of the art and expected progress beyond it, and most importantly the expected impact on metrology, science, standards, and society of the new joint research project - MeDD II, Metrology for Drug Delivery (follow up of project MeDD I). It was selected for funding through the EURAMET EMPIR program of the European Commission and the participating countries. The project started in June 2019 and will last for three years. It involves 15 partners from National and Designated Metrology Institutes, companies, and academia. The main objective is to enable traceable measurements of volume, flow and pressure of existing drug delivery devices (like infusion pumps and analysers) and inline sensors that work at flow rates lower than 100 nL/min, in order to prevent inaccurate measurement results. This project will also investigate fast changing flow rates, liquid mixing behaviour and occlusion phenomena in multi-infusion systems with the purpose of improving dosing accuracy in each infusion line.

Highlights

The most commonly used form of therapy in hospital environment is infusion therapy [1], which implies that drug delivery is a critical aspect in health safety
The new Joint Research Project - MeDD II, Metrology for drug delivery funded under the EMPIR program of the European Commission starts in June 2019, will last for three years involving 15 partners, including: 9 National and Designated Metrology Institutes (IPQPortugal, LNE-CETIAT - France, CMI – Chez Republic, DTI - Denmark, METAS - Switzerland, NEL – United Kingdom, NQIS - Greece, RISE – Sweden and KRISS - Korea), 4 companies (DNV GL – The Netherlands, HSG-IMIT - Germany, INESC MN Portugal, BHT – The Netherlands) and 2 University Hospitals (THL - Germany, UMCU – The Netherlands)
This project is coordinated by IPQ, the Portuguese Institute of Quality and has the overall objective to improve dosing accuracy and enable traceable measurements of volume, flow and pressure of existing drug delivery devices and inline sensors operating at very low flow rates

Summary

Introduction

The most commonly used form of therapy in hospital environment is infusion therapy [1], which implies that drug delivery is a critical aspect in health safety. The new Joint Research Project - MeDD II, Metrology for drug delivery funded under the EMPIR program of the European Commission starts in June 2019, will last for three years involving 15 partners, including: 9 National and Designated Metrology Institutes (IPQPortugal, LNE-CETIAT - France, CMI – Chez Republic, DTI - Denmark, METAS - Switzerland, NEL – United Kingdom, NQIS - Greece, RISE – Sweden and KRISS - Korea), 4 companies (DNV GL – The Netherlands, HSG-IMIT - Germany, INESC MN Portugal, BHT – The Netherlands) and 2 University Hospitals (THL - Germany, UMCU – The Netherlands) This project is coordinated by IPQ, the Portuguese Institute of Quality and has the overall objective to improve dosing accuracy and enable traceable measurements of volume, flow and pressure of existing drug delivery devices and inline sensors operating at very low flow rates (lower than 100 nL/min).

State of the art and progress beyond it

Scientific Objectives

Impact

Conclusion