Abstract
Abstract N,N-Dibutyl-(3,3,3-trifluoro-1-propynyl)amine, prepared readily by the dehydrofluorination of N,N-dibutyl-(2,2,3,3,3-pentafluoropropyl)amine with lithium diisopropylamide at room temperature, smoothly reacted with a variety of aldehydes and ketones in the presence of a catalytic amount of Lewis acid and molecular sieves 4A at ambient temperature to give the corresponding α-(trifluoromethyl)-α,β-unsaturated amides in good to excellent yields with high Z stereoselectivity.
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