New Efficient Ligand-Free, Copper Nanoparticle Catalyzed Coupling Reactions of Aryl Halides with Diethyl Malonate to Produce α-Arylation of Malonates

Abstract

Recently synthesized copper nanoparticles (Cu NP) were used to catalyze coupling of aryl halides with diethyl malonates to produce α-aryl malonates. Synthetic conditions, including solvents, relative amounts of reactants, catalyst, and temperature, etc. have been varied to obtain optimum conditions for such reactions using Cu NP. Unlike well-known cases, the present protocol developed here, with Cu NP, leads to synthesis of a wide variety of products under not very extreme conditions.