New drugs under investigation for the treatment of alopecias

Abstract

ABSTRACTIntroduction: Alopecia is a very common complaint in medical practice, which usually has a large psychological impact in patients. Treatment of alopecia is often difficult and frustrating for patients and clinicians owing to the slow growth rate of the hair, long treatment terms, limited efficacy, and possible adverse side effects.Areas covered: This paper reviews the new and emerging treatments for two of the most common forms of alopecia, known as androgenetic alopecia and alopecia areata. A literature search of PubMed/MEDLINE and ClinicalTrial.gov was performed to gather information about active research on new treatments for alopecias. Websites of companies sponsoring clinical trials were also searched for interim result data.Expert opinion: Many new therapies in two of the most common forms of hair loss have been developed and are currently being studied with encouraging results. In alopecia areata, JAK inhibitors are promising. The discovery of JAK inhibitors has prompted the research and identification of new molecules. In androgenetic alopecia, we are still looking for a topical treatment that is superior to topical minoxidil. However, stem-cell research is advancing and the goal to create new follicles or refresh dormant follicles may be realized in the near future.Trial registration: ClinicalTrials.gov identifier: NCT02299297.Trial registration: ClinicalTrials.gov identifier: NCT03570749.Trial registration: ClinicalTrials.gov identifier: NCT02974868.Trial registration: ClinicalTrials.gov identifier: NCT03137381.Trial registration: ClinicalTrials.gov identifier: NCT03594227.Trial registration: ClinicalTrials.gov identifier: NCT02553330.Trial registration: ClinicalTrials.gov identifier: NCT02561585.Trial registration: ClinicalTrials.gov identifier: NCT03315689.Trial registration: ClinicalTrials.gov identifier: NCT03354637.Trial registration: ClinicalTrials.gov identifier: NCT03651752.Trial registration: ClinicalTrials.gov identifier: NCT03532958.Trial registration: ClinicalTrials.gov identifier: NCT03359356.Trial registration: ClinicalTrials.gov identifier: NCT02018042.Trial registration: ClinicalTrials.gov identifier: NCT02684123.Trial registration: ClinicalTrials.gov identifier: NCT02684097.