Abstract
The renin-angiotensin system (RAS) has an important role in the regulation of blood pressure. Renin is secreted by the kidney and acts on angiotensinogen to form angiotensin I. Although angio-tensin I is not active, it is converted to angiotensin II in a process that is catalyzed by angiotensin-converting enzyme (ACE), as well as by non-ACE pathways. Angiotensin II is a potent vasoconstrictor that can increase blood pressure but also inhibits renin release, thereby creating a negative feedback loop.
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