Abstract
The development of an ophthalmic therapeutic system includes research on the spatial structure of soft contact lens polymers and the study of the processes of saturation and release of medicinal substances from them. This allows you to determine the methods of saturation of contact lenses with medicinal agents and will open up new opportunities in the treatment of ophthalmological diseases. The purpose of this preliminary fragment of large-scale research was to study the surface structure of soft contact lenses made of various polymers. The following polymers were used in the work: Nelfilcon A, Hilafilcon B, Nezofilcon A, Etafilcon A, Lotrafilcon B. The following pharmaceutical substances were used: Brimonidine Tartrate, Betaxolol Hydrochloride, Pyridoxine Hydrochloride. The surface structure of soft contact lenses was studied using atomic force microscopy. Each material under study has a different surface character, which together with the differences in pore properties determines its individuality. Based on this, it should be assumed that the surface of soft contact lenses affects the possibility of their potential use as a means of delivering drug agent molecules to the eye tissues. In all cases of soft contact saturation, the highest absorption capacity was demonstrated by Hilafilcon B and Etafilcon A with a similar surface.
Highlights
In order to fully deliver the drug substance to the tissues of the eye, as well as to increase the time of contact of the drug substance with the conjunctiva, alternative dosage forms for topical application, transport ophthalmic systems, have been developed and introduced into use [1,2,3]
In order to understand the processes of saturation of Soft contact lenses (SCL) with drug solutions, we studied the surfaces of polymers studied by SCL on the basis of their 3D projections obtained by atomic force microscopy
By the end of the saturation process, 0.231 mg of Pyridoxine Hydrochloride was found on the surface of the SCL lenses from Nelfilcon A; Chilafilcon B - 0.249 mg; Nezofilkona A - 0.225 mg; Etafilcon A - 0.240 mg; Lotrafilcon B - 0.227 mg
Summary
In order to fully deliver the drug substance to the tissues of the eye, as well as to increase the time of contact of the drug substance with the conjunctiva, alternative dosage forms for topical application, transport ophthalmic systems, have been developed and introduced into use [1,2,3]. The development of an ophthalmic therapeutic system includes re-search on the spatial structure of SCL polymers, the study of the processes of drug saturation and release from SCL This will make it possible to determine the methods for saturating contact lenses with medicinal agents, the choice of the desired material for SCL and, as a result, will open up new possibilities in the treatment of ophthalmic diseases. The purpose of this preliminary fragment of large-scale studies was to study the surface structure of soft contact lenses from various polymers
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