NEW DOSAGE FORM IN AYURVEDA - THERMO-SENSITIVE VAGINAL GEL OF PVK EXTRACT

Abstract

Rasashastra & Bhaisajya Kalpana is the prime branch of Ayurveda because of the preparation of medicine described in this branch. In ancient times pharmacokinetics of the drug was described in the principle of Dosha and Dushya which is a comprehensive matter for Ayurvedic professionals. But for global acceptance, we need to describe this view (pharmacokinetics) in the form of pharmacological language and convert this ancient medicine in the form of new dosage forms like gel, granules, syrup etc. Panchavalkal Kashaya was described for the treatment of women disease wounds and ulcers in different Ayurvedic texts like Charaka Samhita, Sharangdhara Samhita, Kashyapa Samhita, Bharat Bhaisajya Ratnakar, Bhava-Prakash. In this article, an attempt has been made to describe how to prepare the thermo-sensitive vaginal gel form, of Panchavalkal Kashaya extract for the use of women diseases like leucorrhoea. The thermosensitive gel is in the liquid form at room temperature (20- 25°C) and undergoes gelation when in contact with body fluid (35-37°C). There are many thermo-sensitive polymers like cellulose derivatives, poloxamer, poly (ethylene oxide) /poly (D, L- lactic acid-glycolic acid). Keywords: Ayurveda, Panchvalkal Kashaya, Thermo-sensitive gel, Charaka Samhita.