Abstract

The drugs covered in this volume are restricted to those which have appeared within the past 4 years: the benzothiadiazine, phthalimidine, and spirolactone diuretics, and the antihypertensive agents guanethidine and bretylium, and inhibitors of monoamine oxidase and dopadecarboxylation. The specific investigations reported are introduced by 6 review articles to provide appropriate context. Thus Grollman summarizes the most widely held views of the mechanisms of urine formation and diuretic action; Kirkendall reviews concepts of the mechanisms involved in hypertension; and Imbriglia reviews the pathology of hypertension. In addition, Rennick presents a lucid account of the pharmacodynamics of the new diuretics, based largely on animal studies. Parallel articles for the antihypertensive drugs are presented by Sjoerdsma on monoamine oxidase inhibitors and α-methyl dopa, and by Brodie and Kuntzman on agents selectively depleting catechol amines. Most of the information contained in this volume has been replicated in numerous publications. Bound together as a

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