Abstract
Selective, sensitive, and reproducible ion-selective electrodes containing dabigatran etexilate- phosphotungstate ion pair as a modifier have been fabricated to determine dabigatran etexilate in pure and pharmaceutical dosage form. The modified electrodes ion selective carbon paste electrode and ion selective pencil graphite electrode showed fast and linear responsewithin a concentration range of 1.0 × 10−5to 1.0 × 10−2 M and 1.0 × 10−6to 1.0 × 10−2 M with a detection limit of 4.36 × 10−6 M and 4.26 × 10−7 M by ISCPE and ISGPE, respectively. Electrodes are selective to dabigatran etexilate over common excipients. The present study demonstrated the determination of dabigatran etexilate in pure and pharmaceutical dosage forms with high accuracy and precision.
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