Abstract
Repeated column chromatography using Sephadex LH-20, silica gel (SiO2), and octadecyl SiO2 (ODS) as well as preparative HPLC column chromatography led to isolation of a new dibenzocyclooctadiene lignan along with four known ones, gomisin L2 (1), L1 (2), M1 (3), and M2 (4). Their chemical structures were fixed based on MS, IR, and NMR data analyses. In addition, the stereochemistry of atropisomers, the absolute configuration of the axial chirality in a biphenyl structure, was confirmed by a CD experiment. The new lignan was named gomisin M3 (5).
Highlights
Schisandra chinensis (Turcz.) Baill. is a deciduous vine wood originated from eastern Asia and is distributed in Korea, China, and Japan [1]
The fruits have been utilized for thousands years as a superior drug for therapy of persistent dyspnoea and cough, frequent urination, severe sweating, shortness of breath, hepatitis, diabetes, and wasting-thirsting disease [2]
It has been reported that the pharmacological functions are mostly attributed to lignans, especially the dibenzocyclooctadiene-type lignans [10]
Summary
Schisandra chinensis (Turcz.) Baill. is a deciduous vine wood originated from eastern Asia and is distributed in Korea, China, and Japan [1]. The authors isolated a new dibenzocyclooctadiene-type lignan along with four known ones from the Schisandra chinensis fruits and determined the chemical structure, including absolute configuration of the atropisomers, Nguyen et al Appl Biol Chem (2021) 64:46 through several spectroscopic analyses including a circular dichroism (CD) experiment.
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