New Developments of Differentiation Therapy of Acute Myeloid Leukemia

Abstract

Background: A typical feature of acute myeloid leukemia (AML) consists in the blockade of the cell differentiation process. Many experimental studies have shown that some chemical compounds induce the selective differentiation of hematopoietic cell lines, thus supporting the rationale of using these agents to treat AML by forcing these cells to undergo a process of terminal differentiation. From these studies emerged the potential of all-trans retinoic acid (ATRA) to induce the differentiation of acute promyelocytic cells (APLs) and to treat these patients. The introduction of ATRA in the therapy of these patients improved the treatment of APLs, providing evidence that ATRA, combined with standard chemotherapy or arsenic trioxide (ATO) gives a curative effect in most of these patients. Attempts to emulate the effects of ATRA using other differentiation agents have failed. Keywords: Cell differentiation, clinical trials, differentiation inducers, leukemia, molecular genetics, targeted therapy, therapy.