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Abstract
Parkinson's Disease (PD) is a progressive neurologic disease caused by loss of dopaminergic neurons in the midbrain substantia nigra. Decreased activation of dopamine dependent motor pathways results in the classic features of PD including tremor, bradykinesia, rigidity, and gait impairment. The gold standard treatment of Parkinson's Disease (PD) is levodopa, which acts to replenish deficient endogenous dopamine production, combined with carbidopa, a decarboxylase inhibitor to decrease peripheral breakdown of levodopa.
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