New Developments in the Synthesis of (E)-8-Styrylflavones

Abstract

A novel route for the synthesis of new (E)-8-styrylflavones is reported. This methodology involves the regio- and stereoselective Heck cross-coupling reaction of 8-iodoflavones and styrene derivatives. The Heck precursors, 8-iodoflavones, were obtained through an efficient regioselective one-pot oxidative cyclization–iodination reaction of (E)-2′-hydroxychalcones by applying the iodine/dimethyl sulfoxide system.