Abstract
New Developments in the Pathophysiology and Management of Diabetic Retinopathy
Highlights
The current special issue through a number of experts in the field of Diabetic retinopathy (DR) presents both review and original research articles that provide an overview of the work conducted to date and expand our understanding of the underlying mechanism of DR
Diabetes mellitus is a chronic disorder of glucose metabolism with serious multisystem complications including microvascular dysfunction such as retinopathy, nephropathy, and neuropathy
The clinical use of spectral domain Optical coherence tomography (OCT) has largely contributed to the understanding of pathophysiology of diabetic retinopathy, both in preclinical and clinical phases
Summary
The articles include discussion of the mechanism of retinal neovascularization (angiogenesis, vasculogenesis) and neurodegeneration including the role of enhanced inflammatory pathways, cellular signaling, and oxidative stress. With spectral domain OCT, we are not yet at cellular level, but we may obtain and discuss individual retinal layers. The clinical use of spectral domain OCT has largely contributed to the understanding of pathophysiology of diabetic retinopathy, both in preclinical and clinical phases.
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