Abstract
AbstractA novel reagent, which introduces two sulfur atoms in one step, was designed and used for the construction of diverse disulfanes by copper‐catalyzed oxidative cross‐coupling under mild reaction conditions. By applying this stable and readily prepared reagent, late‐stage modification of pharmaceuticals and natural products can be achieved straightforward. The scaled‐up experiments further indicated the practicality of this protocol. The pH value of the system plays a key role in achieving highly selective cleavage of the C−S bond instead of a S−S bond in the transformation.
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