Abstract
In this study 26 new oligophenol cellulase inhibitors were discovered from wheat straw pretreatment liquors.
Highlights
Lignocellulosic conversion processes have the potential to provide the future society with environmentally friendly energy and platform chemicals.[1,2,3,4,5] A challenge is to make the biorefinery processes economically competitive and a cost driver in biorefinery processes are the enzymes that are utilised in the first lignocellulosic saccharification
The formation of inhibitors during pretreatment of lignocellulosic feedstocks is a persistent problem, and notably the compounds that retard enzymatic cellulose conversion represent an obstacle for achieving optimal enzymatic productivity and high glucose yields
The compounds extracted into 2-butanone were found to exert profound inhibition of cellulolytic glucose release on both pure cellulose and pretreated wheat straw fibers, and the compounds left in the aqueous phase exerted profound inhibition
Summary
Lignocellulosic conversion processes have the potential to provide the future society with environmentally friendly energy and platform chemicals.[1,2,3,4,5] A challenge is to make the biorefinery processes economically competitive and a cost driver in biorefinery processes are the enzymes that are utilised in the first lignocellulosic saccharification. It can be hypothesised that other still unidentified compounds can be potent inhibitors as well, since compounds with multiple chemical functionalities are formed during biomass pretreatment,[6] and give rich possibilities for various chemical reactions to take place and form many new potential inhibitor compounds. The objective of this work is to reveal the chemical identity of the most potent cellulase inhibitors and consider their synthesis routes in order to understand the origin of the compounds and hinder their formation
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