Abstract
The sterol composition of the sponge Dysidea fragilis, coming from the lagoon of Venice, has been investigated; our results confirmed the variability of D. fragilis biochemistry. The sponge elaborates, in addition to eight usual 3β-hydroxy sterols, thirteen polyhydroxysterols, eight of them ( 6–13) were novel compounds. Their structures were established by spectroscopic data. New compounds 3β,5α,6β,7α-tetrahydroxy-cholest-8(9)-en-11-one ( 8), 3β,5α,6α-trihydroxy-9,11-secocholest-7-en-9-one ( 9) and 3β,5α,6α,9α-tetrahydroxy-cholest-7-ene-6-sulfate ( 11) were proved to be cytotoxic on two different tumor cell lines in vitro.
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