Abstract
The sponge Cacospongia scalaris from Tarifa Island, Spain, contains in addition to five known compounds (1−5), the new scalarane sestertepenes 18-epi-scalaradial (6), 19-dihydroscalaradial (7), 12-epi-acetylscalarolide (8), and 16-acetylfuroscalarol (9) together with three uncommon norscalaranes norscalaral A (10), norscalaral B (11), and norscalaral C (12). The structures were elucidated by interpretation of spectral data. 18-epi-Scalaradial (6) represents the missing stereoisomer on structure−activity studies carried out with compounds of this series and did not react with methylamine. The new compounds isolated from C. scalaris showed significant in vitro cytotoxicity against five tumor cell lines with 18-epi-scalaradial showing the greatest activity (ED50 = 0.2 μg/mL).
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