Abstract
Bioassay-guided fractionation of the extract of Jamaican marine sponge Plakortis sp. followed by preparative TLC and HPLC yielded several known methyl ester cyclic peroxides (1a, 2a, 3a, 4, 5), known plakortides (6,7), known bicyclic lactone (8) and new cyclic peroxide acids (1b, 2b, 3b). The chemical structures were elucidated by extensive interpretation of their spectroscopic data. These natural products showed remarkable in vitro cytotoxicity against several cancer cell lines.
Highlights
Sponges of the genus Plakortis are well known among marine chemists as prolific producers of biologically active secondary metabolites
As a part of systematic endeavors to isolate bioactive compounds from marine organisms, we have investigated constituents of the sponge Plakortis sp., collected at depths of -10 to -20 m in the Discovery Bay, Jamaica
The fractions were monitored by cytotoxicity bioassays using proliferating mouse cell lines: NIH3T3, KAI3T and Vero cells to afford, in order of elution, eleven compounds (1-8)
Summary
Sponges of the genus Plakortis are well known among marine chemists as prolific producers of biologically active secondary metabolites. The 1H NMR spectrum of 1b contained signals that were typical of cyclic peroxides having the plakortin ring system and a side chain.[10] It exhibited three olefinic multiplets at 5.13, 5.09 and a double doublet of doublets at 4.46.
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