Abstract
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Highlights
Drugs 2012, 10 and P-388 cell lines as determined by standard procedures. [25,26] Bioassay-guided fractionation of the extract resulted in the isolation of six new cembranolides, michaolides L–Q (1–6), together with the known cembranolide, lobomichaolide (7) [2,3] (Figure 2)
The α-exo-methylene-γ-lactone moiety is important for cytotoxicity by comparing the cytotoxicity of 4 with those of 1–3, 5, and 6 [4]
Cytotoxicity was determined on P-388, HT-29, and A-549 tumor cells using a modification of the MTT colorimetric method according to a previously described procedure [25,26]
Summary
Soft corals of the genus Lobophytum (Alcyoniidae) have been reported as a rich source of secondary metabolites endowed with a range of structural diversity and various biological activities [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24]. Previous bioassay results of some cembranoids and their analogues have demonstrated remarkable pharmacological potential such as cytotoxicity against various cancer cell lines [2,3,4,5,6,7,8,9], anti-inflammatory properties [11,12,13], antimicrobial activities [11], and HIV-inhibitory activity [14]. In previous papers [2,3,4], we reported the isolation of several cytotoxic cembranolides, lobomichaolide, crassolide, and michaolides A–K from samples of the soft coral Lobophytum michaelae Tixier-Durivault (Alcyoniidae) (Figure 1). [25,26] Bioassay-guided fractionation of the extract resulted in the isolation of six new cembranolides, michaolides L–Q (1–6), together with the known cembranolide, lobomichaolide (7) [2,3] (Figure 2) (human colon adenocarcinoma) and P-388 (mouse lymphocytic leukemia) cell lines as determined by standard procedures. [25,26] Bioassay-guided fractionation of the extract resulted in the isolation of six new cembranolides, michaolides L–Q (1–6), together with the known cembranolide, lobomichaolide (7) [2,3] (Figure 2)
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