Abstract
Due to the rapidly increasing number of pathogenic bacteria, viruses, and tumor cells that possess resistance toward established therapies, lead structures for the development of new drugs are in high demand. The plant material of Tanacetum sinaicum is considered a prolific source of the potent biologically active sesquiterpene Tanacetolide A (1). In our research, we focused on the structural transformation of the substrate Tanacetolide A (compound 1) by suspended culture of the novel locally isolated terrestrial fungus Rhizopus oryzae KX685359. The fungal transformation resulted in the formation of 1β,3α‐dihydroxy‐6α‐hydroperoxy‐eudsm‐4(15)‐ene 12‐oic acid (2) with higher antiproliferative activity against colon cancer cell line (Caco‐2) than that of the parent compound (1).
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