Abstract
Bryonia aspera Stev. ex Ledeb from the Cucurbitaceae family is native to Iran. This plant has been described in an ethnobotanical study as being used as a treatment of dermal wounds, cancer and digestive disorders [1], whereas no phytochemical investigations have been reported up to now. The isolation of bioactive compounds from this plant seemed to be of interest because a chloroform extract showed cytotoxic activity. Therefore a phytochemical investigation of the root extract has been undertaken and yielded 11 compounds. Their structures were elucidated by spectroscopic means (1D- and 2D-NMR spectroscopy, ESI-MS). The majority of the compounds turned out to be 23,24-dihydro-cucurbitacin derivatives.
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