Abstract
Six new cyclic peroxides (1–6) were isolated from the Korean sponge Plakortis simplex, along with two new alkylpyridinium alkaloids (7 and 8). The structures of these compounds were completely determined by a combination of NMR analysis and chemical reactions. Compounds 1–6 exhibited cytotoxic/antifungal activities against RAW264.7 cells and Candida albicans.
Highlights
Sponges of the family Plakinidae have provided structurally noble and biologically active metabolites including alkaloids, glycolipids, lactones and polyketides [1,2,3,4,5]
As part of our search for new metabolites from the extracts of the Korean sponges, we isolated six cyclic peroxides (1–6) from fractions of Plakortis simplex which showed toxicity against C. albicans in a disk agar diffusion method
Compound 1 was determined to have a molecular formula of C18H32O5 on the basis of high-resolution fast-atom bombardment mass spectrometry (HRFABMS) and the 13C NMR spectrum, which was consistent with three degrees of unsaturation
Summary
Sponges of the family Plakinidae have provided structurally noble and biologically active metabolites including alkaloids, glycolipids, lactones and polyketides [1,2,3,4,5]. Numerous polyketides containing a five- or six-membered peroxide group have been isolated from Plakinidae since the identification of plakortin in 1978 [6,7,8,9,10]. These compounds exhibited several biological activities, such as cytotoxic, antifungal, and antimalarial properties, making them potentially useful in the development of drugs or as research tools [11,12,13]. We describe the isolation, stereostructural characterization of all of the isolated compounds, together with activities for six peroxide compounds
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