Abstract
Clostridium difficile infection is transmitted via spores, and the disease is mediated via secreted toxins. It represents a significant healthcare problem, and clinical presentation can range from asymptomatic carriage to life-threatening pseudomembranous colitis. publications in the field, with a focus on recent developments and concepts. infection control measures, antibiotic stewardship and current management of the initial episode of C. difficile infection. selection and sequence of interventions for the management of recurrent C. difficile infection; management of persistent carriers of toxigenic C. difficile in patients at high risk of subsequent C. difficile infection. use of faecal microbiota transplantation for recurrent C. difficile infection. role of specific microbiota-mediated interventions and vaccination in the treatment and prevention of C. difficile infection.
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