Abstract
One new sesquiterpene lactone, corialactone E (1), one new neolignan, coriarianeolignan A (2), together with three known apocarotenoids (3-5) and one known neolignan (6) have been isolated from a CHCl3 extract of the roots of Coriaria nepalensis. The structures including absolute configurations of 1-6 were elucidated through extensive NMR, HR-ESIMS, and CD data analysis. Structurally, compound 1 possessed novel variations in the structure, including the newly formed ether ring of C-3/O/C-9 and the lactone ring connecting C-13 and C-5. Compound 5 showed cytotoxic activity against SKOV3 (human ovarian cancer) cells with IC50 values of 4.67μmol/L. In vivo system, compound 3 showed anti-convulsant activity by 34% at the dose of 5mg/kg.
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